Anubha Anti-Ageing Medicine

Number  1  Volume 1 JANUARY 2010

Dear Anubha visitors
This first edition of Anubha News is dedicated to  planning for healthy longevity. A
few rare individuals out of 6 billion people, have managed to live to 110 years of age
and beyond. These super-centenarians appear to have achieved their longevity
through their own personal formulas some which appear to have no obvious scientific
logic. However, there seem to be some common themes: simple lifestyles, remaining
active, family involvement, laughter  and possibly a whole lot of favourable genes.
The reality for the vast majority of human beings is a lifespan of just over 80 years
which is considered a 'good innings'. All too often I hear of people losing their life to
cancer or heart disease in their 20's, 30's 40's or 50's.

Can we optimise our chances of longevity enough to make a substantial difference
through the mine-fields of innate genetic aberrations (polymorphisms), electro-
magnetic pollution, and toxic food and air and negotiating the stresses of 21st
century living?

Lifespan has advanced with the changing centuries. Unconscious abuse of our bodies
through excessive exposure to natural phenomena (like the sun) or man made
pollution (nuclear radiation and chemical pollution from hydrocarbon xenobiotics or
toxic metals in our teeth, food, water or air), can induce levels of illness and

With demineralization and devitaminisation of our foods through over chemicalisation
of our soils, and pollution of our waterways including drug residues of antibiotics,
steroids and  potent synthetic oestrogens and progestins entering  the water, not to
mention radiation and chemical pollution from above, the adage ‘just eat a well
balanced (Australian) diet’ is a potentially harmful past-time.

Plastic water bottles that we carry with us every day and conveniently believe to be
inert (safe) is not necessarily the case. Phthalate placticisers (PETE- polyethylene
terephthalate), designated as '1' in the triangular icon at the bottom of the bottle in
these drinking bottles are considered hormone disruptors and may suppress normal
steroidogenesis. It is recommended by the manufacturers that these bottles are only
drunk out of once and not reused. It is wise not to leave these bottles in sunshine
either. Children are more prone to enhanced absorption of phthalate residues. Water
is a highly absorbable medium and plastic residues enter our ‘pure spring water’ and
we have no knowledge of it, or its consequences.

Chlorine sterilizers our water, but how safe is it for our health? Bromide whitens
garlic and can compete and displace essential minerals in our diet and halogenic
florins are released from Teflon coated frying pans.

Vaccinations, which we believe are protecting our children from harmful viruses and
bacteria, may actually be harming them irrevocably through the absorption of
mercury from the thimerosal additive, which is a mercury analogue.

In spite of all the evidence as to the lethality and morbidity of mercury, thimerosal
continues to be part of many immunizations given to babies and adults alike. Recently
a few thimerosal-free vaccinations have become available.

We are now learning from early gene testing, that there are millions of possible
polymorphisms on the 20000 to 30000 genes which each of us has. However, what is
critical is that genes which are highly significant for human functioning are either not
polymorphic or if they are, then that polymorphism enhances the activity of the
gene's encoded protein to enhance healthier function.  This is eloquently seen a
northern Italian community who have a CETP (cholesteryl ester transfer protein)
gene polymorphism. This gene encodes a protein to remove cholesterol from the HDL
molecule and 'give' it to the LDL molecule. Persons with a variant polymorphism  
(mutation) of this gene, perform the transfer of cholesterol less well i.e. keep the HDL
molecule 'rich', have a better chance of longevity and reaching a hundred.

SNPs (Single Nucleotide Polymorphisms) of genes for detoxification can have major
health outcomes in combination with lifestyles not conducive to health. Absence of a
major antioxidant gene Glutathione-S-Transferase M1 (GSTM1) compromises our
capacity to detoxify chemical cocktails and has been correlated with an increased risk
in a range of cancers especially lung cancer especially in tobacco smokers.

The seemingly benign (and enjoyable) world-wide practice of drinking coffee, may
have sinister consequences, if you have a CYP1A2 SNP, as this gene  encodes an
enzyme (the CYP1A2 enzyme), which is almost solely responsible for detoxification of
caffeine. The CYP1A2 SNP has been associated with an increased risk of acute
myocardial infarction, as the number of cups of coffee increases above one per day.

Eating a generic diet may in principle be seemingly appropriate but may be bad news
for your genes. From the emerging field of Nutrigenetics and Nutrigenomics we are
learning that diet is very person specific.  

Through gain-of-function evolutionary genetic mutations, some ethnic groups have
adapted to foods (e.g. Caucasians of northern Europe have a higher  tolerance of
cows milk products which many ethnic Africans do not have).

Anti Ageing tips: becoming 'Street-wise'
Enjoy the sun for short periods in the early morning or late afternoon.
Maintain high normal reference ranges of Vitamin D.

Use plastic bottles once only if coded '1' in the triangular icon on the bottom of the
bottle. '2' and '4' are safer and can be reused.

Avoid Teflon or use high quality at a low heat and replace damaged pans.

Assess your level of mercury and other heavy metals and avoid exposure of such
poisons to yourself and your children wherever possible.

Research systems of detoxification to neutralise inadvertent exposure. Spirulina,
chlorella, curcumin from turmeric are valuable detoxifying nutrients. We are all
poisoned with heavy metals. It is just a matter of how your body is capable of dealing
with the conjugation and removal of these organ damaging poisons.

Heavy metals are hormone disruptors, immune disruptors, and have no biological
health function in the body. Assess your toxic metal status through blood testing if
there has been acute exposure, hair testing for general heavy metal and nutritional
mineral screening and provocation testing with DMPS, DMSA or EDTA for specific
toxic metals analysis.

Have a gene test and assess your genotype.

Any attempt of longevity should be on the basis of sound water, food and air and the
conscientious avoidance and removal of heavy metals and xenobiotic poisons.

Knowing your genes, may help you to move from generic principles our healthy living
to person specific genetic facts about how your body runs and what food to eat and
what chemicals to avoid and which pathways (hormonal/enzymatic) to support and

Comprehensive gene testing is available through Anubha Mountain Health Retreat
(see 'Genetic Screening'). Contact us at to discuss gene testing.

Anubha Anti-Ageing News is a new portal of current health-affirming news and
reviews of how we can care for ourselves and loved ones better, and enjoy radiant
health for longer.

No2, Vol 1

Anti-Ageing Medicine at Anubha embraces both physical, mental and spiritual
rejuvenation. Skin ageing is affected by environmental influences, by lifestyle
practices and by endogenous factors like our genes and their encoded proteins
including hormones as well as by non-genetic factors like organ dysfunction.

As our skin ages, its ability to repair is reduced. Its recovery and versatility is
compromised. Worst of all it starts looking old and loses is sculptured beauty.
Removing or avoiding free-radicals from your immediate external environment (e.g.
excess sun) can slow the damage. However what we breathe, what we eat and our
hormonal status may also contribute to our skin health.

Genetics and epigenetics can impact skin vitality.
Genes and their encoded proteins which may benefit us when we are young, become
a menace as we age. This is known as pleomorphic antagonism.
Growth signaling proteins (kinases) support (beautiful) growth when young,
promote signs of ageing/disease or cancer later in life. Blocking signal transduction
of growth promoting kinases can block cancer or the signs of ageing (wrinkles).

Unblocking suppressed (protective) genes supports skin and organ longevity.
a genetic level to effect anti-ageing results.

Many chemical based anti-ageing products work on a superficial cellular level.
Pg & iso-PG act as GENETIC SWITCHES turning on silenced genes (silenced with
ageing) and turn off tumour promoting genes activated with ageing.

PG and iso-PG and phenylbutyrate are pro-drugs for naturally occuring amino-acid
derivertives which were discovered Dr Stanislaw Burzynski in 1968 as part of his PhD
thesis. They are peptides which are small amino acid molecules, existing naturally in
the human body and in many foods.

Genomic profiling in ageing animals, shows upregulation in the IGF/AKT signaling
pathway and down regulation of PTEN  (increased risk cancer skin damage /
cardiovascular disease).

Based on DNA microarray studies: PG decreases the activity of AKT2 (oncogene).
PG increases activity of PTEN (a tumour suppressor gene).

PG and iso-PG have been shown to unmethylate TSG's and methylate oncogenes
improving DNA stability and decreasing the potential risk of cancer as well as
inhibition of deacetylation of histones which allows (appropriate) gene expression.  

PG and iso-PG are now available in a cream/lotion. This cosmoceutical cream and
lotion Aminocare has been developed by Dr Burzynski.

Active ingredients are: Phenylacetylglutamine (PG)  Phenylacetyl iso-glutamine (iso-
PG), which have a specific blocking effect on genes that promote skin ageing (AKT,
IGF-1, RAS and mTOR); stimulation of specific tumour suppressor genes (TSG's)-p16
and PTEN that have been methylated and/or deacetylated.

4 week trial 22 volunteers no skin pathology apart from wrinkles
Applied Aminocare cream to one area of crow’s feet wrinkles (treated side)
Untreated side-control side
Variables: tolerance, efficacy, acceptibility were monitored
Tolerance: Pre-trial back patch test. No reaction to the product  =inclusion in trial.
Efficacy: Silicon imprint of treated and non-treated sides beginning and end of study-
laser profilometry measure skin topography wrinkle (depth/volume & complexity)
Acceptability: Questionnaires
TOLERANCE: No reactions-excellent tolerance
EFFICACY: End of trial wrinkle depth, volume complexity all improved
ACCEPTIBILITY: Responses-very satisfactory-softness, suppleness, skin comfort,
ease of application and penetration. 19/22 desired to continue product.
PG and iso-PG may have an anti-tumour effect as well as an skin anti-ageing effect.
Wrinkle depth, complexity and volume appears to decrease, when applied two times
Results through research can occur in 1 months time.

This cream and lotion is available through Anubha products.

To contact Anubha telephone 03 6239 1572
or email

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