Anubha Anti-Ageing Medicine

FUNCTIONAL LIVER DETOXIFICATION PROFILE

The liver is responsible for multiple enzymatic processes and the production of crucial antioxidants to
prevent the irrevocable process of oxidation or human rusting. If the liver's detoxification processes
are dysfunctional, this can promote degenerative diseases, including an increased risk of cancer.
Recognition of detoxification weaknesses allows for personalised dietary correction and specific
nutritional supplementation.

The liver has multiple routes of detoxification. This test assesses the phase I cytochrome p450 (CYP)
enzyme activity as measured by CYP 1A1 activity, following a dose of caffeine which is metabolised by
CYP1A1. Abnormally low or high CYP1A1 activity indicates poor or excessive caffeine clearance from
saliva. This may be suggestive of liver exhaustion or enzyme induction respectively, reflecting
xenobiotic contamination or genetic up-regulation. Phase II testing measures the ability of amino acid
complexes (including glutathione, sulphur amino acids [methionine, taurine, cysteine], glucaric acid
and glycine) to complete the next level of detoxification. This process converts fat soluable
intermediary free radical residues into water soluble metabolites for excretion. Normal phase I and II
are necessary for safe detoxification of potential poisons, drugs, chemicals and hormones.

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