Anubha Anti-Ageing Medicine
Parent oestrogens (Oestrone and Oestradiol) are metabolised into hydroxylated forms of oestrogens
which have varying degrees of both safety and risk as far as breast, ovarian and prostate cancers are
concerned. Knowing these metabolites and their ability to be further metabolised into a water-soluble
and excretable form (methoxylated oestrogens) provides valuable information as high levels of some
of the hydroxylated oestrogens may increase the risk of oestrogen related cancers under toxic
environmental (xenoestrogenic) influences. Knowledge of the specific ratios of these metabolites
directs treatment strategies.
Urinary steroid metabolites of progesterone, Pregnanadiol and Pregnanotriol equate to used
progesterone and are a valuable diagnostic marker to assess cellular progesterone before and after
treatment. Since adequate progesterone is necessary for the conversion of inactive cortisone to active
cortisol, low progesterone levels often correlate with the clinical signs of cortisol
Cortisol metabolites can be detected through 24 hour urine testing and provide information as to the
relationship Cortisol metabolites between active cortisol and inactive cortisone through the tetrahydro
cortisol/sone metabolites. These metabolites may be relevant when symptoms of fatigue, anxiety,
depression, weight loss or gain or low libido are present.
TESTOSTERONE AND ANDROSTENEDIONE METABOLITES
Testosterone and Androstenedione Metabolites assess the active metabolites of these hormones via
alpha reductase enzyme activity and inactive metabolites via beta reductase enzyme activity,
suggesting the Androgenic Index ratio.
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