Anubha Anti-Ageing Medicine

ONCOGENETICS

Is the study of genes which can promote the increased risk of cancer. There are many known
monogenic gene relationships with cancer. These are heritable traits in families where there is strong
penetrance of the gene in successive generations and a high likelihood of the manifestation of a
tumourous condition.

This is well documented with the BRCA1 and BRCA2 (breast cancer one and breast cancer 2 genes).
However more recently studies have concentrated on lower penetrance genes which are not
necessarily passed down through families.

As single gene candidates for cancer, there is a very low risk but, which in combination with other low
penetrance genes and adverse environmental circumstances, Genome Wide Association Studies
(GWAS) have located genes which are associated with a higher risk of cancer.

Where it may be impossible to overcome the phenotypic expression of a high penetrance gene,
knowledge of low penetrance polymorphic genes and manipulation of diet and lifestyle may be critical
in preventing a disease occurrence.

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